A field experiment was conducted for two consecutive years to study the effect of lime, farmyard manure and fertilizers application on growth, yield and quality of soybean (Glycine max L. Merrill) in an acid soil of Nagaland. The experiment was laid down in split-split plot design with 24 treatment combinations comprising of three levels of lime i.e., L0: 0 kg ha-1, L1: 400 kg ha-1 and L2: 10% of LR as main plot, two levels of FYM i.e., O0: 0 t ha-1 and O1: 5 t ha-1 as sub-plot and four levels of fertilizers i.e., I0: 0% RDF, I1: 50% RDF, I2: 75% RDF and I3: 100% RDF as sub-sub plot which were replicated thrice. Plant height was found to be significantly higher during the entire period of plant growth where treatments received lime, FYM and fertilizers in adequate amounts. The same trend was observed in case of number of leaves, number of nodules and dry weight of nodules. Treatment L2O1I3 gave significantly higher stover yield (4549.11 kg ha-1), seed yield (2301.33 kg ha-1) and number of pods plant-1 (95.83) than rest of the treatments. Oil content in seed was not significantly affected by the treatments however, oil and protein yield were higher in L2O1I3 treatment. Highest available NPKS (400.63 kg ha-1, 24.78 kg ha-1, 109.09 kg ha-1 and 0.45 mg kg-1 respectively) content at harvest was associated with treatment of L2O1I3.