There have been tremendous change in the global forest cover in the past 50 years, which has directly or indirectly exerted significant impact on the global environment change. Quantitative analysis of forest cover change in a regional area is formulated by remote sensing and GIS from past four decades throughout the globe. The core scientific issues to quantitatively analyze are the major environmental problems alarming globally. This paper widely analyzed the importance of the healthy forest cover of a region, and then it shows the effects which progressively introduce the forest cover change. The vital role of monitoring the cover change has been conducted by the Remote Sensing and GIS. The primary scientific issues about the impacts of forests cover change on the regional climate and reviewed the progress in relevant researches. Finally, this paper discussed the application of the Remote Sensing using to detect the forest cover change and its regional impacts.