An experiment was conducted to evaluate the efficacy of novel insecticides with seven treatments on infestation of tomato fruit borer (H. armigera) at JNKVV, Krishi Vigyan Kendra, Chandan Nagar Chhindwara (M.P.) during the Rabi season of 2018-19. Among seven treatments, minimum larval population (0.53 larva/plant) existed in the treatment chlorantraniliprole 18.5 SC. Next effective treatment was spinosad 45 SC (0.69 larva/plant) which was comparable with treatment indoxacarb 14.5 SC (0.68 larva/plant). The rest of treatments viz., emamectin benzoate 5 SG, profenofos 50 EC, Azadiractine, were recorded 0.86, 1.05, 1.20 larval population per plant of H. armigera, respectively. The minimum fruit damage in the treatment chlorantraniliprole 18.5 SC (8.72%) was found most effective against fruit borer followed by spinosad 45 SC (10.78%), indoxacarb 14.5 SC (11.18%) and emamectin benzoate 5 SG (13.08%). Profenophos (15.98%) and Azadirachtin (17.19%) proved least effect. All the insecticides significantly increased the yield of marketable fruits of tomato over control. The maximum yield (443.15 q/ha) was recorded in Chlorantraniliprole followed by Spinosad (434.65 q /ha), Indoxacarb (427.34 q/ ha) and Emamectin benzoate 5 SG (418.64 q/ha). The minimum yield was observed in profenophos (341.62 q/ ha) followed by Azadirachtin (324.18 q/ha).