A field study was conducted during 2018-19 on “Effect of integrated nutrient management (INM) on morpho-physiological and yield of safed musli” at KRC college of Horticulture, Arabhavi, Gokak, Karnataka. The research results revealed that plant supplied with panchagavya recorded maximum leaf area (581.57 cm²), leaf area index (1.29), CGR (2.13 g m² day^-1 at 30-60 DAP), fresh root yield (31.15 g plant^{-1 ­}and 33.42 q ha^-1), dry root yield (5.77 q ha^-1) and fresh peeled root yield (21.34 g plant^-1). Among inorganic and organic source of nutrients application, 100 per cent RD NPK 50:40:40 kg ha^-1 recorded significantly maximum leaf area (635.71 cm²), LAI (1.41), CGR (3.47 g m²day^-1), significantly fresh root yield (36.16 g plant^-1 and 36.26 q ha^-1, respectively), fresh peeled root yield (26.40 g plant^-1) and dry root yield of 6.33 q ha^-1. Among interaction, application of panchagavya (3%) + 100 per cent RD NPK 50:40:40 kg ha^-1 recorded significantly maximum leaf area (671.05 cm²), LAI (1.49), CGR (3.70g m²day^-1), significantly highest fresh peeled root yield (30.51g plant^-1) and fresh root yield (38.34 q ha^-1).