Methicillin-resistant Staphylococcus aureus (MRSA) is increasingly recognized in infections among persons in the community without established risk factors for MRSA. Besides the resistance to antibiotics, their capability to form biofilm also increased the pathogenicity of MRSA. Garlic exhibits broad pharmaceutical properties and inhibitory activities against MRSA. This work investigated the synergistic effect of garlic mediated silver nanoparticles against MRSA. The synthesized garlic mediated silver nanoparticles are characterised by UV-Visible spectrophotometer and SEM analysis. It shows a peak at 420nm in UV-Visible spectrum and on SEM analysis it is estimated that the synthesised nanoparticles are spherical in morphology, regular in shape with 100 nm particles. Both antibacterial and antibiofilm activity of AgNPs were determined by microtitre plate method. The garlic extract by itself shows antibacterial activity of approximately 22.8%, 30.6%, 40.9% and 50.8% for the application of 25μl, 50μl, 75μl and 100μl respectively. Whereas the antibacterial activity of garlic mediated silver nanoparticles for the identical concentration were 50.5%, 62.7%, 73.6% and 74.7% in approximate respectively. Likewise, antibiofilm activity of garlic extract was obtained as 19.5%, 29.5%, 31.7% and 40.1% correspondingly for the concentrations of 25μl, 50μl, 75μl and 100μl. While, 34.9%, 39.4% 49.4% and 66.9% of antibiofilm activity was shown by garlic mediated silver nanoparticles in that order of concentration. Antibacterial and antibiofilm activity of garlic mediated silver nanoparticles was owing to the synergistic properties of garlic and silver in nanosize. Thus the results pay way for new medical innovation.