The study was conducted in Davanagere district of Karnataka state during the year 2019-20 to study the knowledge and adoption of Betel vine cultivation practices followed by the farmers. A total of 120 respondents were randomly selected based on betel vine cultivation area. Farmers are interviewed using a pre-tested interview schedule. Majority of the betel vine farmers had medium (76.67%) to low (15.83%) knowledge level. More than half of respondents had medium (65.00%) to high (18.33%) adoption level with respect to betel vine cultivation practices. Hence, there is a need to provide training programmes through KVKs and Agricultural department to enhance the level of knowledge and adoption of betel vine production technology.