Centella asiatica is well known medicinal plants in herbal trades of India. It is commonly known as Brahmi, Gotu kola, mentioned as one of the oldest herb in medicinal systems. The diverse range of pharmacological properties validates by scientific studies with relevant to ethnomedicinal uses of Centella. The plant shows its potential as respiratory disorders, hepatic, spasmodic, cardiovascular and especially neural disorders. The literature on chemical constituents in every parts from root to leaves can prove more valuable pharmaceuticals for human health. Rapid advancement in the era of biotechnology with such type of herbs as trouser horse and create boon to pharmaceutical-industry. Various ethnomedicinal reports on local and traditional home remedies, proliferation of books, theories of medicinal practitioners were reported every years validates by documentation and research every year. In this review, approach was made to document the pharmacological and pharmaceutical uses. Numerous health care products using Centella formulations are already available in the market but always chance of new drug derivatives from a plant using phytochemicals will be there.