Podophyllum hexandrum Royle (Himalayan Mayapple) was commonly known as Bantrapushi or Giriparpat, Bankakri, Kanda-ri-mokri, Rikhpat, Papra, Aindri (a divine drug) in ancient times. It is also known as ‘May apple’ as the fruit ripening occurs in the spring season. This plant has already proven its potential, as it shows the properties of antioxidants, antibacterial, antifungal, antiviral, anticancer and insecticidal. Podophyllum has also got attention due its remarkable importance in various medicinal systems, either allopathic, homeopathic or amchi, because of its highly extensive therapeutic potential. However, the decline in species frequency for the last few years has drawn attention of many scientific bodies. This review paper gives a brief highlight on the phytochemical and pharmacological properties of P.hexandrum and its importance to mankind on pharmaceutical aspects related to this endangered plant.